Calcium Carbonate + P-5-P + Combination Tablets

Mechanism

• Calcium Carbonate: Provides elemental calcium, essential for bone mineralization and muscle function.
• Vitamin D3: Enhances calcium absorption and regulates bone metabolism.
• Methylcobalamin: Active form of Vitamin B12, supports red blood cell formation and neurological health.
• L-Methylfolate Calcium: Active folate form, regulates homocysteine metabolism and DNA synthesis.
• Pyridoxal-5-Phosphate: Coenzyme form of Vitamin B6, essential for amino acid metabolism and neurotransmitter synthesis.

Pharmacokinetics

• Calcium Carbonate: Absorbed in small intestine, bioavailability enhanced by Vitamin D3.
• Vitamin D3: Fat-soluble, stored in liver and adipose tissue.
• Methylcobalamin: Absorbed in ileum with intrinsic factor, stored in liver.
• L-Methylfolate Calcium: Rapidly absorbed, bypasses folate metabolism defects.
• Pyridoxal-5-Phosphate: Active coenzyme, directly utilized in metabolic pathways.

Side Effects

• Mild gastrointestinal upset
• Headache
• Rare: allergic reactions

Contraindication

• Hypersensitivity to any component
• Pregnancy unless prescribed
• Severe hepatic or renal impairment

Interaction

• Anticonvulsants: May interfere with folate metabolism.
• Iron supplements: Calcium may reduce absorption.
• Other B-vitamins: Possible synergistic effects.

Warning and Precautions

• Monitor calcium levels in long-term use.
• Use cautiously in patients with renal impairment.
• Not recommended in pregnancy without medical advice.
• Discontinue if severe gastrointestinal upset occurs.

Dosage

As directed by the Physician.